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Active Pharmaceutical Ingredients 5

Prominent & Leading Wholesale Trader from Ahmedabad, we offer tolnaftate anti-fungal agent, topiramate powder, guaifenesin powder, brinzolamide powder, tizanidine hcl and trihexyphenidyl hcl.

Tolnaftate Anti-Fungal Agent

Tolnaftate Anti-Fungal Agent
  • Tolnaftate Anti-Fungal Agent
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Molecular FormulaC19H17NOS
IUPAC NameO-2-naphthyl methyl(3-methylphenyl)thiocarbamate
CAS Number2398-96-1

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete’s foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.

Synonyms:
  • 2-Naphthyl N-Methyl-N-(3-Tolyl)Thionocarbamate;Methyl 3-Tolylthiocarbamic Acid O-Naphthalen-2-Yl Ester;Methyl-[3-Methylphenyl]-Carbamothioic Acid O-2-Naphthyl Ester;Tolnafrate;Tolnaftate;Aftate;Carbamothioic Acid, Methyl(3-Methylphenyl)-, O-2-Naphthalenyl Ester;Carbanilic Acid, M,N-Dimethylthio-, O-2-Naphthyl Ester

Application:
  • Tolnaftate topical is used to treat skin infections such as athlete''s foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete''s foot.
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Topiramate Powder

Topiramate Powder
  • Topiramate Powder
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Molecular FormulaC12H21NO8S
IUPAC Name2,34,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
CAS Number97240-79-4

This compound belongs to the dioxolopyrans. These are compounds containing a dioxolopyran moiety, which consistts of a dioxole ring fused to a pyran ring.

Synonyms:
  • Topina; Topamax; Topimax; EpitoMa; TopaMac; TopoMax; MCN 4853; EpitoMax; RWJ 17021; Topiramate

 

Application:

  • Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Indicated for the treatment and management of obesity.
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    Guaifenesin Powder

    Guaifenesin Powder
    • Guaifenesin Powder
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    IUPAC NAME(RS)-3-(2-methoxyphenoxy)propane-1,2-diol
    CAS NO.93-14-1
    FORMULAC10H14O4
    SYNONYMS2-G;2/G; g87; gge; G 87; Dilyn; Gvaja; my301; Resil; Resyl
    GradeBio-Tech
    Product TypeChemical

    An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
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    Brinzolamide Powder

    Brinzolamide Powder
    • Brinzolamide Powder
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    Grade StandardReagent Grade
    Purity (in %)99%
    IUPAC NAME (5R)-5-ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2 6,9-dithia-3-azabicyclo[4.3.0]nona-71
    CAS NO. 138890-62-7
    FORMULA C12H21N3O5S3
    SYNONYMS AL 4;Azopt;AL-4682;AL 4862;BRINZOLAMIDE;BIRNZOLAMIDE;Brinlolamide;Brinzolamide (200 mg);(4R
    Product TypeChemical

    Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
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    Tizanidine HCL

    Tizanidine HCL
    • Tizanidine HCL
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    Physical StatePowder
    Molecular FormulaC9H8CIN5S HCL
    ApplicationMuscle Relaxant
    IUPAC Name6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-7-amine
    CAS Number64461-82-1

    Tizanidine HCl is a skeletal muscle relaxant and centrally acting α2-AR (α2-adrenergic) agonist. Displays affinity for the I1-imidazoline receptor and exhibits spasmolytic activity.

     

    Synonyms:

    • Ab-021; Gibonz; Zanpeak; Ternelin; Sirdalud; Zanaflex; Enchinin; Astonelin; Ds-103-282;T Izanidine HCL
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    Trihexyphenidyl HCl

    Trihexyphenidyl HCl
    • Trihexyphenidyl HCl
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    Grade StandardBio-Tech Grade
    ApplicationAnticholinergic,Antiparkinsonian
    IUPAC Name1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
    CAS Number52-49-3
    Molecular FormulaC20H31NO

    A white to off white powder, odorless

     

    Synonyms:

    • Tremin; win511; peragit; pipanol; Broflex; Sedrina; Trihexy; paralest; pacitane; cyclodol
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    Zonisamide Powder

    Zonisamide Powder
    • Zonisamide Powder
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    Physical StatePowder
    IUPAC NameBenzo[d]isoxazol-3-ylmethanesulfonamide
    CAS Number68291-97-4
    Molecular FormulaC8H8N2O3S
    ApplicationFor use as adjunctive treatment of partial seizures in adults with epilepsy.

    Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.

    Synonyms:
    • ZON; ci-912; ad-810; pd110843; excegram; exceglan; Excegran; Zonegran; Excemide; Zonisamide
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    Amodiaquine HCL

    Amodiaquine HCL
    • Amodiaquine HCL
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    IUPAC NAME4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
    CAS NO.69-44-3
    FORMULAC20H28Cl3N3O3
    SYNONYMSAmodiachin Hydrochloride,Amodiaquini Hydrochloridum
    GradeBio-Tech

    For treatment of acute malarial attacks in non-immune subjects.It is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. Amodiaquine hydrochloride has been tried in the treatment of giardiasis and hepatic amoebiasis. It has also been tried, with variable success, in the treatment of lepra reactions, lupus erythematosus, rheumatoid arthritis, and urticaria (Martindale, 1989).
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    Diacerin Powder

    Diacerin Powder
    • Diacerin Powder
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    Physical StatePowder
    CAS NO.13739-02-1
    FORMULAC19H12O8
    SYNONYMSDiacerhein; 4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid; 4,5-bis(acetyloxy)-
    GradeBio-Tech

    Diacerin is also known as Diacetylrhein. Diacerein is used for treatment of Osteoarthritis. It works by inhibiting the synthesis of Interlukin-1, the main cytokine involved in cartilage destruction and enhances the synthesis of Proteoglycans & Hyluronic Acid which are the principal components of cartilage.
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    Tazarotene Powder

    Tazarotene Powder
    • Tazarotene Powder
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    IUPAC NameEthyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate
    CAS Number118292-40-3
    Molecular FormulaC21H21NO2S
    ApplicationUsed to treat psoriasis, acne and sun damaged skin.

    Tazarotene (marketed as Tazorac, Avage and Zorac) is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage).

    Synonyms:
    • Zorac; Tazorac; agn190168; TAZAROTENE; Tazorac/zorac; Tazarotene(Avage); Tazarotene 99% Min; 6-[2-(3,4-Dihydro-4,4-diMethyl-2H-1-benzothiopyran-6-yl)ethynyl]-; ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate; 3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y
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    Terbutaline Sulphate

    Terbutaline Sulphate
    • Terbutaline Sulphate
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    ApplicationAnti Asthmatic
    IUPAC Name5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
    CAS Number23031-32-5
    Molecular FormulaC24H40N2O10S

    A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.

    Synonyms:
    • Terbul; Convon; Brethine; Monovent; Bricanyl; Brithine; Butalire; Butaliret; Terbasmin; Brethaire
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    Triprolidine HCL

    Triprolidine HCL
    • Triprolidine HCL
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    IUPAC Name2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrate hydrochloride
    CAS Number6138-79-0
    Molecular FormulaC19H23ClN2
    ApplicationAnticholinergic (opthalmic)

    Crystalline Powder, having no more than a slight, but unpleasant odour.

     

    Synonyms:

    • Rate, Stereoisomer; Triprolidine Hcl Usp; Trans-Triprolidinehcl; Tripolidine Hydrochloride; Triprolidine Hydrochloride; Triprolidine Hcl Monohydrate; Triprolidinehydrochloride,Usp; Triprolidinesigmareferencestandard; Triprolidine Hydrochloride (500 Mg); Triprolidine Hydrochloride (300 Mg)
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    Undecylenic Acid

    Undecylenic Acid
    • Undecylenic Acid
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    IUPAC NameUndec-10-enoic acid
    CAS Number112-38-9
    Molecular FormulaC11H20O2
    SynonymsSodium undec-10-enoate; 10-Undecenoic acid

    Clear to pale yellow liquid

     

    Application:

    • Used as antifoaming and surface active agent. As its sulfo – succinate derivative it is used in anti-dandruff shampoos.
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    Valsartan Powder

    Valsartan Powder
    • Valsartan Powder
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    IUPAC Name(S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid
    CAS Number137862-53-4
    Molecular FormulaC24H29N5O3
    Synonyms5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; CGP 48933; Diovan; Nisis; Tareg

    This compound belongs to the biphenyltetrazoles and derivatives. These are organic compounds containing a biphenyl attached to a tetrazole. A carbon atom of the biphenyl moiety is boned to a carbon or the nitrogen atom of the tetrazole moiety.

     

    Application:

    • May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.
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    Voglibose Powder

    Voglibose Powder
    • Voglibose Powder
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    Physical StatePowder
    IUPAC Name(1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol
    CAS Number83480-29-9
    Molecular FormulaC10H21NO7

    This compound belongs to the aminocyclitols and derivatives. These are cyclitols with at least one hydroxyl group replace by an amino group.

     

    Synonyms:

    Voglibose; 3,4-Dideoxy-4-[[2-Hydroxy-1-(Hydroxymethyl)Ethyl]Amino]-2-C-(Hydroxymethyl)-D-Epiinositol; 3,4-Dideoxy-4-[[2-Hydroxy-1-(Hydroxymethyl)Ethyl]Amino]-2-C-(Hydroxymethyl)-D-Epinositol; 5-(1,3-Dihydroxypropan-2-Ylamino)-1-(Hydroxymethyl)Cyclohexane-1,2,3,4-Tetrol;Voglibose, 99+%; A 71100; Ao 128;Basen

     

    Application:

    • For the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
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    Xylometazoline HCL

    Xylometazoline HCL
    • Xylometazoline HCL
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    ApplicationVasoconstrictor, used as a nasal decongestant.
    IUPAC Name2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
    CAS Number1218-35-5
    Molecular FormulaC16H24N2.HCL

    A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion.

     

    Synonyms:

    • Olynth; Novorin; Xymelin; Brizolin; Therapin; Galazolin; Neo-Rinoleina; Xylonetazolinehcl; Neo-Ii; Xylometazoline HCL
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    Ziprasidone HCL

    Ziprasidone HCL
    • Ziprasidone HCL
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    CAS Number138982-67-9
    FormPowder
    Applicationantipsychotic;Dopamine D2/serotonin 5-HT2 antagonist
    Molecular FormulaC21H21ClN4OS.ClH.H2O

    White to slightly pink powder.

     

    Synonyms:

    • 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one Hydrochloride Monohydrate

     

    IUPAC Name:

    • 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one hydrate hydrochloride
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      Cyclophosphamide Powder

      Cyclophosphamide Powder
      • Cyclophosphamide Powder
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      IUPAC Name(RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
      CAS Number50-18-0
      Molecular FormulaC7H15CI2N2O2P
      ApplicationOncology

      Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients

      Synonyms:
      • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
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      Erythromycin Estolate

      Erythromycin Estolate
      • Erythromycin Estolate
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      IUPAC Name[(2S,3R,4S,6R)-4-(dimethylamino)-2
      CAS Number3521-62-8
      Molecular FormulaC40H71NO14,C12H26O4S
      ApplicationMacrolides Antibiotics

      Erythromycin Estolate belongs to macrolide antibiotics. It is the dodecyl sulfate(slat) of erythromycin 2''-propionate. It is mainly used in the treatment of the infections of staphylococcus resistant to penicillin and also used in the patients with the infections of streptococcus and pneumococcus and diphtheria bacilli carrier.

      Synonyms:
      • Erythromycin 2''-propionate dodecyl sulfate

       

      IUPAC Name:

      • [[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] propanoate;dodecyl hydrogen sulfate
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        Telmisartan Powder

        Telmisartan Powder
        • Telmisartan Powder
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        Molecular FormulaC33H30N4O2
        CAS Number144701-48-4
        Molar mass514.617 g/mol

        Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.

        Synonyms:
        • Tu-199; Pritor; Bibr 277; Micardis; Telmisaran; Timishatan; Bibr 277Se; 21829-25-4; Telmisartan; Timetazidine

         

        Application:

        • Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors).

         

        IUPAC Name:

        • 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid

         

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          Timolol Maleate

          Timolol Maleate
          • Timolol Maleate
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          CAS Number26921-17-5
          Molecular FormulaC13H24N4O3S.C4H4O4
          ApplicationAnti hypertensive,Anti-glaucoma

          Timolol Maleate is a adrenergic receptor antagonist selective for β1-AR. Adrenergic receptors, or adrenoreceptors, are G-protein coupled receptors involved in a variety of sympathetic nervous system processes. Antagonists such as Timolol Maleate that affect the β adrenoreceptors are commonly known as beta blockers that decrease cardiac output.

          Synonyms:
          • S-(-)-1-(t-Butylamino)-3-[(4-morpholino- 1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt

           

          IUPAC Name:

          • (Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
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          Tinidazole Powder

          Tinidazole Powder
          • Tinidazole Powder
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          IUPAC Name1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole
          CAS Number19387-91-8
          Molecular FormulaC8H13N3O4S

          A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.

           

          Synonyms:

          • Pleti; pletil; cp12574; bioshik; fasigyn; fasigin; tricolam; simplotan; sorquetan; tinidazol

           

          Application:

          • For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients. Also for the treatment of giardiasis caused by G. duodenalis in both adults and pediatric patients older than three years of age and for the treatment of intestinal amebiasis and amebic liver abscess caused by E. histolytica in both adults and pediatric patients older than three years of age.
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          Tolterodine Tartrate

          Tolterodine Tartrate
          • Tolterodine Tartrate
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          ApplicationA muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
          CAS Number124937-52-6
          Molecular FormulaC26H37NO7

          Tolterodine L-Tartrate is a muscarinic receptor antagonist that is active at all mAChR M subtypes. This compound blocks the opening of ion channels by acetylcholine, which in turn leads to muscle relaxation by blocking neuronal signaling.

          Synonyms:
          • Detrol; Detrol La; Detrusitol; Pnu-20058E; Pnu-200583E; Tolerodinetartrate; Tolterodine(Detrol); Tolterodine Tartrate; Tolterodine L-Tartrate; Tolterodine Tartrate Api

           

          IUPAC Name:

          • (2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(1S)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol

           

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          Triclosan Agent

          Triclosan Agent
          • Triclosan Agent
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          IUPAC Name5-chloro-2-(2,4-dichlorophenoxy)phenol
          CAS Number3380-34-5
          Molecular FormulaC12H7CI3O2

          Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.

          Synonyms:
          • ch3565; Irgasan; Trox-100; Triclosan; Cloxifenol; Zilesanuw.; Trichlosan; Irgacare Mp; Irgasandp300; Triclosan USP

           

          Application:

          • Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.
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          Tropicamide Compound

          Tropicamide Compound
          • Tropicamide Compound
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          IUPAC NameN-ethyl-3-hydroxy-2-phenyl-N- (pyridin-4-ylmethyl) propanamide
          CAS Number1508-75-4
          Molecular FormulaC17H20N2O2

          This compound belongs to the phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.

          Synonyms:
          • mydrum; mydrin;mydriat; ro1-7683; Mydrapid; ydriacyl; Epitromin; epitromina; Tropicamid;ropicamide

           

          Application:

          • Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
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          Clobetasol Propionate

          Clobetasol Propionate
          • Clobetasol Propionate
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          CAS Number25122-46-7
          Molecular FormulaC25H32CIFO5
          SynonymsOlux; Psorex; Clobex; Olux-E; cgp9555; GR-2/92; Karison; clobesol; Temovate; CCl 4725

          This compound belongs to the gluco/mineralocorticoids, progestogins and derivatives. These are steroids whose structure is based on an hydroxylated prostane moiety.

          Synonyms:
          • Olux; Psorex; Clobex; Olux-E; cgp9555; GR-2/92; Karison;clobesol; Temovate; CCl 4725

           

          Application:

          • For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
           
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