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Capsaicin is a chili pepper extract, genus Capsicum, with analgesic properties. Since its discovery, it is used as a homeopathic remedy to treat burning pain using the concept of "treating like with like" or counter-irritant.

It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

Ranolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina.

Synonyms:

• Ranolazine; n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide; 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine; CVT 303; RS 43285-003;1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]

 

IUPAC Name:

• (RS)-N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]piperazin-1-yl]acetamide

 

Application:

• For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.

Relaxes smooth muscles by stimulating beta2-receptors, thereby causing bronchodilation and vasodilation



Application Bronchodilator, antiasthmatic

Diacerein is also known as Diacetylrhein. Diacerein is used for treatment of Osteoarthritis.
It works by inhibiting the synthesis of Interlukin-1, the main cytokine involved in cartilage destruction and enhances the synthesis of Proteoglycans & Hyluronic Acid which are the principal components of cartilage.

Selective serotonin reuptake inhibitor (SSRI).


A selective serotonin reuptake inhibitor

This medicine is an antifungal used to treat certain fungal infections of the skin. Treatment of tinea pedis, tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouinii, Microsporum gypseum and Epidermophyton floccosum. Treatment of cutaneous candidiasis and tinea versicolor.

Tadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the “weekend pill.” This longer half-life also is the basis of current investigation for tadalafil’s use in pulmonary arterial hypertension as a once-daily therapy.

Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness.