Active Pharmaceutical Ingredients

Product Details:

This compound belongs to the hydroxysteroids. These are compounds containing an steroid backbone, with at least one hydrogen substituted by an hydroxyl group.

Synonyms:

• Organon;Turinal;gestanin;gestanol;gestanon;gestanyn;orageston;NSC 37723;allyl-estreno;ALLYLESTRENOL

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This compound belongs to the gluco/mineralocorticoids, progestogins and derivatives. These are steroids whose structure is based on an hydroxylated prostane moiety.

Synonyms:

• bp2; QVAR; kw-053; Viarex; Viarox; aldecin; Aerobec; Anceron; Beclate; beclacin

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Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Synonyms:

• Zylate; Scabide; ASCABIN; Benylate; Colebenz; Scabagen; Scabanca; Scabitox; Scobenol; Vanzoate

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Betamethasone 21-phosphate sodium salt is a corticosteroid with anti-inflammatory and immunosuppressive abilities. Betamethasone 21-phosphate sodium salt is used where water retention is undesirable.

Synonyms:

• Betamethasone 21-phosphate disodium; bentelan; betamethasonedisodiumphosphate

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A white or almost white, crystalline powder.

Synonyms:

• Emcor; Isoten; Zebeta; Soprol; Concor; Monocor; Azopsin; Seafuri; Well-Bi; Emd33512

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White crystalline or amorphous powder, having a faint odour suggestive of burnt sugar.

Synonyms:

• levucal;flanthin; mil-u-cal; laevucalcin; levulincalcid; Calciumlevulate; calciumpharmacon; LCIUM LEVULINATE; calcium-diasporal; calcium laevulate

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Cetrimide is used as an active pharmaceutical ingredient (API), an antispetic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treatingseborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums.

Synonyms:

• TTAB; MTAB; mytab; MitMAB; morpant; Cetrimide; tetradonium; quaternium13; MicrocideIitm; Tetradoniumbromid

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Fine white unctuous crystalline powder, having a faint odour

Synonyms:

• Cap-P; Detreopal; Chloropal; Chlorambon; Cap-Palmitate; Clorolifarina; Chloromycetinpalmitate; Chloramphenicol Palmitate; Chloramphenical Palmitate; Chloramphenicolpalmitate, Bp

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Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.

Synonyms:

• ADAPALENE;6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHALENE CARBOXYLIC ACID;6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID;6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid;Adapalen;6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid;CD-271;Differi

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Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.

Application:

• Ambroxol is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.

 

Synonyms:

• Mucosolvan; Ambroxol Hcl; Ambroxolhydrocloride; Ambroxolhydrochlo ride(Ep2001/Cp2000); Trans-4-((2-Amino-3,5-Dibromobenzyl) Amino) Cyclohexanol, Hcl;4-[(2-Amino-3,5-Dibromo-Benzyl) Amino] Cyclohexanol Hydrochloride; 4-[(2-Amino-3,5-Dibromophenyl)Methylamino] Cyclohexan-1-Ol Hydrochloride; 4-[(2-Azanyl-3,5-Dibromo-Phenyl) Methylamino] Cyclohexan-1-Ol Hydrochloride;2-Amino-3,5-Dibromo-N-[Trans-4-Hydroxycyclohexyl] Benzylamine Hydrochloride;Trans-4-[[(2-Amino-3,5-Dibromophenyl)Methyl] Amino] Cyclohexanol Monohydrochloride

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A White or almost white, crystalline powder, sparingly soluble in water and in propylene glycol, very slightly soluble in alcohol

Synonyms:

• CHX;U-4527; LISIUM; NSC-185;ay 5312; ACTIDION; ACTIDONE; ACTI-AID; ArlacideH; ANTI-DIONE

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Aceclofenac belongs to a group of Non Steroidal Anti-inflammatory Drugs (NSAIDs) used to treat various painful inflammatory conditions. The mode of action of aceclofenac is largely based on the inhibition of prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclooxygenase, which is involved in the production of prostaglandins. The Drugs inhibits synthesis of the inflammatory cytokines interleukin (IL)-1 and tumor necrosis factor and prostaglandin E2 (PGE2) production.

Synonyms:

• 2-(2-(2-(2,6-dichlorophenyl)aminophenyl)acetyl)oxyacetic acid, 2-((2,6-dichlorophenyl)amino)-benzeneacetic acid carboxymethyl ester, [({2-[(2,6 dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid.

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Acriflavine is an topical antiseptic agent and has also been used for the treatment of external fungal infections.

Synonyms:

• 3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine

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Acriflavin Neutral acts as an intercalating dye and also reported to inhibit mitochondriogenesis. An antiseptic. It has been used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.

Synonyms:

• Euflavin; Acriflavin; Mixture of 3,6-Diamino-10 methylacridinium chloride and 3,6-acridinediamine; Chromoflavine; Neutroflavine; Xanthacridine; Acriflavon; Trypaflavine; Gonacrine; Gonacrin; Panflavin

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Relaxes smooth muscles by stimulating beta2-receptors, thereby causing bronchodilation and vasodilation

Synonyms:

• 1-(4-Hydroxy-3-Hydroxymethylphenyl)-2-(Tert-Butylamino)Ethanolsulfate;Asmaven Sulfate;Cobutolin;2-(Tert-Butylamino)-1-(4-Hydroxy-3-Hydroxymethylphenyl)Ethanol Hemisulfate;5-[2-(Tert-Butylamino)-1-Hydroxyethyl]-2-Hydroxybenzyl Alcohol Hemisulfate;Alpha1-[(Tert-Butylamino)Methyl]-4-Hydroxy-1,3-Benzenedimethanol Hemisulfate Salt;Alpha-1-[[(1,1-Dimethylethyl)Amino]Methyl]-4-Hydroxy-1,3-Benzenedimethanol Hemisulfate;Alpha1-[[(1,1-Dimethylethyl)Amino]Methyl]-4-Hydroxy-1,3-Benzenedimethanol Sulphate

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Alendronate is a nitrogen-containing, second generation bisphosphonate. Bisphosphonates were first used to treat Paget’s disease in 1971. This class of medications is comprised of inorganic pyrophosphate analogues that contain non-hydrolyzable P-C-P bonds. Similar to other bisphosphonates, alendronate has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate inhibits farnesyl pyrophosphate synthetase, one of the enzymes in the mevalonic acid pathway involved in producing isoprenoid compounds that are essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras and Rab. Inhibition of this process interferes with osteoclast function and survival. Alendronate is used for the treatment of osteoporosis and Paget’s disease.

Synonyms:

• G-704650; Alendronate Sodium Salt; Alendronate, Sodium Salt Trihydrate; Alendronate Sodium Trihydrate;Alendronnate Sodium Trihydrate; Alendronic Acid, Monosodium Salt, Trihydrate; Adronat; 4-Amino-1-Hydroxybutylidine-1,1-Bisphosphonate Sodium Salt Trihydrate

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Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.

Synonyms:

• Endep; Deprex; Amitid; Domical; Etrafon;Saroten; Triavil; Amiplin; Normaln; Rantoron

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AmlodipineBesylate is a long-acting calcium channel blockerdihydropyridine (DHP) class] used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure; in angina, it increases blood flow to the heart muscle (although DHP-class calcium channel blockers are more selective for arteries than myocardium, as the cardiac calcium channels are not of the dihydropyridine-type).

Synonyms:

• 3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate

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A clear or almost clear liquid or a solid crystalline mass, colourless or slightly yellow when freshly prepared, which darkens on keeping; odour, characteristic. Amylmetacresol should be protected from light.

Application:

• Amylmetacresol is an antiseptic used to treat minor infections of the mouth and throat. It is one of two active ingredients in Gorpils lozenges or Strepsils. Boots Group or Gepach International also make a lozenge with this as active ingredient.

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Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.

Application:

• Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified.

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Artesunate is a derivative of artemisinin and belongs to a class with antimicrobial properties. The compound is an active ingredient in the Chinese herb Artemisia annua and has been used in Malaria studies. Artesunate has been tested against 55 cell lines and demonstrated anti-cancer activity. Research shows that conditional expression of CDC25A heightens the sensitivity of tumor cells to artesunate.

Synonyms:

• AsuMax; Cosunate; Saphnate; WR-256283; ARTESUNATE; PlasMotriM; PlasMotrin; Qinghaozhi; Vartesunate; Arteannuinum

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A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect. This compound belongs to the phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.

Synonyms:

• Noten;Unilo;Altol;Ateni;Seles;Xaten;tenlol;atenol;uniloc;Alinor

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Atorvastatin Calcium Salt is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor, the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Inhibition of HMG-CoA reductase results in a drastic reduction in the production of cholesterol and other isoprenoids. Competitive inhibitors of the reductase are believed to induce the expression of LDL (Low Density Lipoprotein) receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol.

Synonyms:

• Tahor; Ci-981; Ym-548; Sortis;Lipitor; Pd134298-38A; Atorvastatin Ca; Atorvastatin 3S,5S-Atorvastatin; Alorvastin Calcium

 

Application:

• The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease.

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Benzydamine hydrochloride locally acts as a nonsteroidal anti-inflammatory with local anesthetic and analgesic properties.

Synonyms:

• af864; tamas; verax; tantum; difflam; enzamin; imotryl; indolin; ririlim; riripen

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Betamethasone Acetate, Micronized, USP is a strong glucocorticoid steroid and has anti-inflammatory and immunosuppressive properties. It has the added advantage of not causing water retention, unlike other potent drugs of this type. This item is formulated as a topical cream, ointment, lotion, gel or even foam. It is listed on the World Health Organization's list of essential medicines.

Synonyms:

• Betamethasone 21-Ace; Betamethasone Acetate; Betamethasone 21-Acetate; Betamethasone21-Acetatemicro; Betamethasone Acetate (500 Mg); Betamethasone Acetate Bp/Usp/Ep; Betamethasoneacetate, Micronized,Usp; Betamethasone Acetate Mm(Crm Standard); Betamethasone Acetate Usp(Crm Standard); Betamethasone Acetate Epb(Crm Standard)

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Betamethasone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid

Synonyms:

• Betamethasone Dipropionate Mm(Crm Standard);Betamethasone Dipropionate Usp(Crm Standard)

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Betamethasone Valerate acts as a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Synonyms:

• betamethasone pentanoate; Betamethasone Valerate; 1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate; 9-Fluoro-11beta, 17,21-trihydroxy-16bet; methylpregna-1,4-diene-3,20-dione 17-valerate; VALISONE (11-beta, 16-beta)-l)oxy); 17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-9-fluoro-11-bet; 17-valerate; Betamethasonevalerateester; betnovateat; celestoderm; (11beta,16beta)-9-fluoro-11, 21-dihydroxy-16-methyl-3, 20-dioxopregna-1,4-dien-17-yl pentanoate; 9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate; (8xi,14xi,16beta)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate

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Biperiden hydrochloride is a muscarinic receptor (mAChR M) antagonist that displays some selectivity for the mAChR M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for mAChR M1, mAChR M4, mAChR M3, mAChR M2 and mAChR M5 receptors, respectively)

Synonyms:

• Bicamol; Akiriden; Tasmolin; NSC 84989; NSC 170950; BIPERIDINE HCL; Biperidene HCL; akinetonhydrochloride; BIPERIDEN HYDROCHLORIDE; biperidinehydrochloride

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Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction as well as part of bowel preparation before medical examinations, such as for a colonoscopy.

Synonyms:

• laco; Bicol; LA96A; ivilax; Laxans; laxine; neolax; zetrax; deficol; durolax

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Bromhexine hydrochloride is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells.

Synonyms:

• Bisolvon; Cofmesin; Hapysuol; Coughtimi; Bromessina; Bisopollon; Breviscapine; Bromhexine Hcl; Bromhexinechloride; Bromhexine Hcl Bp98

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(R)-(+)-Bupivacaine Hydrochloride is a local anaesthetic used for epidural and intrathecal anaesthesia.

Synonyms:

• 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

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A white or almost white hygroscopic Powder.

Synonyms:

• Calcium Dobesilate; Calcium Dobesilate Mnohydrate; Calium Dobesilate Monohydrate; Calcium Dobesilate 1-Hydrate;2,5-Dihydroxybenzenesulfonic Acid, Calcium Salt;2,5-Dihydroxy-Benzenesulfonic Aci Calcium Salt; Dexium;Doxium

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A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

Synonyms:

• RELA; Apesan; Arusal; cb8019; Flexal; Mioril; Sanoma; Brianil; Calenfa; Cariso

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Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.

Synonyms:

• COREG; Carca; Kredex; Querto; Artist; Carloc; Carvas; DQ-2466; Artione; Cadilan

 

Application:

• For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

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Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form.

Synonyms:

• Celebrex;Celecoxib; 4-[[5-(4-Methylphenyl)-3-Trifluoromethyl]-1H-Pyrazol-Yl] Benzenesulfonamide; 4-[5-((4-Methylphenyl)-3-Trifluorpmethyl)-1H-Pyrazol-Yl] Benenesulfonamide; Celecoxib, 4-[5-(4-Methylphenyl)-3-Trifluoromethyl)-1H-Pyrazol-Yl] Benzenesulfonamide; Benzenesulfonamide, 4-5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl-;4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl] Benzenesulfonamide;Celebra

 

Application:

• For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis

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White or almost white powder

Synonyms:

• Triz; Cesta; Ryzen; Zeran; ZYRTEC; Alerid; Cetrak; Riztec; Virlix; Zirtec

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Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Synonyms:

• Bactigras; Arlacide A; 10,040Diacetate; Hibitaneacetate; Hibitane Diacetate; Chlorhexidinecitrate; Chlorhexidine Diacet; Chlorhexidine Acetate; Chlorhexidine Acatate; Chlorohexidine Acetate

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An almost colourless, or pale-yellowish liquid.

Synonyms:

• Abacil; D00858;d-)(2:1; hibidil; placout; septeal; unisept; corsodyl; disteryl; orahexal

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The medicine is widely utilized to prevent blood clots and helps in smooth flowing of bloodstream through the veins.

Synonyms:

• Acenocoumarol-D5;4-Hydroxy-3-[1-(4-Nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one-d5;Acenocoumarin-d5;G-23350-d5;Nicoumalone-d5;Sinthrome-d5;Sintrom-d5

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White to off white crystalline powder

Synonyms:

• Ly 139603; Strattera; Atomoxetine; Atomoxitine; Atomoxetine Hcl; Atomoxetine Hci; Atomoxitine Hcl; Tomoxetine Hydrochloride; Atomoxetine Hydrochloride; R-Tomexetine Hydrochloride

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Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. [PubChem] The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.

Application:

• The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis.

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